| 9/3/2005 | Alabama A&M | 27 | @ | Tennessee St | 14 | ||||
| 9/10/2005 | Jackson St | 14 | vs | Tennessee St | 20 | OT | Memphis TN | ||
| 9/17/2005 | Tennessee St | 20 | @ | Tennessee-Martin | 42 | OVC | |||
| 9/24/2005 | Florida A&M | 12 | vs | Tennessee St | 7 | Atlanta GA | |||
| 10/1/2005 | NC A&T | 16 | vs | Tennessee St | 3 | Indianapolis IN | |||
| 10/13/2005 | Tennessee St | 31 | @ | Tennessee Tech | 20 | OVC | |||
| 10/22/2005 | Jacksonville St | 33 | @ | Tennessee St | 3 | OVC | |||
| 10/29/2005 | Tennessee St | 11 | @ | Samford | 31 | OVC | |||
| 11/5/2005 | Eastern Illinois | 27 | @ | Tennessee St | 3 | OVC | |||
| 11/12/2005 | Tennessee St | 24 | @ | SE Missouri St | 32 | OVC | |||
| 11/19/2005 | Eastern Kentucky | 49 | @ | Tennessee St | 10 | OVC |