| 9/3/2005 | South Florida | 13 | @ | #3 Penn State | 23 | ||||
| 9/10/2005 | Cincinnati | 24 | @ | #3 Penn State | 42 | ||||
| 9/17/2005 | Central Michigan | 3 | @ | #3 Penn State | 40 | ||||
| 9/24/2005 | #3 Penn State | 34 | @ | Northwestern | 29 | B10 | |||
| 10/1/2005 | Minnesota | 14 | @ | #3 Penn State | 44 | B10 | |||
| 10/8/2005 | #4 Ohio State | 10 | @ | #3 Penn State | 17 | B10 | |||
| 10/15/2005 | #3 Penn State | 25 | @ | #20 Michigan | 27 | B10 | |||
| 10/22/2005 | #3 Penn State | 63 | @ | Illinois | 10 | B10 | |||
| 10/29/2005 | Purdue | 15 | @ | #3 Penn State | 33 | B10 | |||
| 11/5/2005 | #20 Wisconsin | 14 | @ | #3 Penn State | 35 | B10 | |||
| 11/19/2005 | #3 Penn State | 31 | @ | Michigan St | 22 | B10 | |||
| 1/3/2006 | #22 Florida St | 23 | vs | #3 Penn State | 26 | Orange |