| 9/3/2005 | Miami-Ohio | 14 | @ | #4 Ohio State | 34 | ||||
| 9/10/2005 | #2 Texas | 25 | @ | #4 Ohio State | 22 | ||||
| 9/17/2005 | San Diego St | 6 | @ | #4 Ohio State | 27 | ||||
| 9/24/2005 | #25 Iowa | 6 | @ | #4 Ohio State | 31 | B10 | |||
| 10/8/2005 | #4 Ohio State | 10 | @ | #3 Penn State | 17 | B10 | |||
| 10/15/2005 | Michigan St | 24 | @ | #4 Ohio State | 35 | B10 | |||
| 10/22/2005 | #4 Ohio State | 41 | @ | Indiana | 10 | B10 | |||
| 10/29/2005 | #4 Ohio State | 45 | @ | Minnesota | 31 | B10 | |||
| 11/5/2005 | Illinois | 2 | @ | #4 Ohio State | 40 | B10 | |||
| 11/12/2005 | Northwestern | 7 | @ | #4 Ohio State | 48 | B10 | |||
| 11/19/2005 | #4 Ohio State | 25 | @ | #20 Michigan | 21 | B10 | |||
| 1/2/2006 | #4 Ohio State | 34 | vs | #5 Notre Dame | 20 | Fiesta |