| 9/3/2005 | South Florida | 13 | @ | #3 Penn State | 23 | ||||
| 9/10/2005 | Florida A&M | 3 | @ | South Florida | 37 | ||||
| 9/17/2005 | UCF | 14 | @ | South Florida | 31 | ||||
| 9/24/2005 | #15 Louisville | 14 | @ | South Florida | 45 | BigE | |||
| 10/1/2005 | South Florida | 7 | @ | #9 Miami-Florida | 27 | ||||
| 10/15/2005 | South Florida | 17 | @ | Pittsburgh | 31 | BigE | |||
| 11/5/2005 | South Florida | 45 | @ | Rutgers | 31 | BigE | |||
| 11/12/2005 | South Florida | 27 | @ | Syracuse | 0 | BigE | |||
| 11/19/2005 | Cincinnati | 16 | @ | South Florida | 31 | BigE | |||
| 11/26/2005 | South Florida | 10 | @ | Connecticut | 15 | BigE | |||
| 12/3/2005 | #11 West Virginia | 28 | @ | South Florida | 13 | BigE | |||
| 12/31/2005 | North Carolina St | 14 | vs | South Florida | 0 | Meineke |