| 9/3/2005 | Kent St | 14 | @ | Michigan St | 49 | ||||
| 9/10/2005 | Hawaii | 14 | @ | Michigan St | 42 | ||||
| 9/17/2005 | Michigan St | 44 | @ | #5 Notre Dame | 41 | OT | |||
| 9/24/2005 | Michigan St | 61 | @ | Illinois | 14 | B10 | |||
| 10/1/2005 | #20 Michigan | 34 | @ | Michigan St | 31 | B10 | |||
| 10/15/2005 | Michigan St | 24 | @ | #4 Ohio State | 35 | B10 | |||
| 10/22/2005 | Northwestern | 49 | @ | Michigan St | 14 | B10 | |||
| 10/29/2005 | Indiana | 13 | @ | Michigan St | 46 | B10 | |||
| 11/5/2005 | Michigan St | 21 | @ | Purdue | 28 | B10 | |||
| 11/12/2005 | Michigan St | 18 | @ | Minnesota | 48 | B10 | |||
| 11/19/2005 | #3 Penn State | 31 | @ | Michigan St | 22 | B10 |