| 9/5/2005 | #9 Miami-Florida | 7 | @ | #22 Florida St | 10 | ACC | |||
| 9/10/2005 | The Citadel | 10 | @ | #22 Florida St | 62 | ||||
| 9/17/2005 | #22 Florida St | 28 | @ | #19 Boston College | 17 | ACC | |||
| 10/1/2005 | Syracuse | 13 | @ | #22 Florida St | 38 | ||||
| 10/8/2005 | Wake Forest | 24 | @ | #22 Florida St | 41 | ACC | |||
| 10/15/2005 | #22 Florida St | 21 | @ | Virginia | 26 | ACC | |||
| 10/22/2005 | #22 Florida St | 55 | @ | Duke | 24 | ACC | |||
| 10/29/2005 | Maryland | 27 | @ | #22 Florida St | 35 | ACC | |||
| 11/5/2005 | North Carolina St | 20 | @ | #22 Florida St | 15 | ACC | |||
| 11/12/2005 | #22 Florida St | 14 | @ | #23 Clemson | 35 | ACC | |||
| 11/26/2005 | #22 Florida St | 7 | @ | #16 Florida | 34 | ||||
| 12/3/2005 | #11 Virginia Tech | 22 | vs | #22 Florida St | 27 | ACC | ACC CG | ||
| 1/3/2006 | #22 Florida St | 23 | vs | #3 Penn State | 26 | Orange |