| 9/2/2005 | Indiana | 20 | @ | Central Michigan | 13 | ||||
| 9/10/2005 | Central Michigan | 38 | @ | Miami-Ohio | 37 | MAC | |||
| 9/17/2005 | Central Michigan | 3 | @ | #3 Penn State | 40 | ||||
| 9/24/2005 | Eastern Michigan | 23 | @ | Central Michigan | 20 | OT | MAC | ||
| 10/1/2005 | Central Michigan | 31 | @ | Akron | 17 | MAC | |||
| 10/8/2005 | Central Michigan | 14 | @ | Army | 10 | ||||
| 10/15/2005 | Ohio | 10 | @ | Central Michigan | 37 | MAC | |||
| 10/29/2005 | Toledo | 17 | @ | Central Michigan | 21 | MAC | |||
| 11/5/2005 | Northern Illinois | 31 | @ | Central Michigan | 28 | MAC | |||
| 11/12/2005 | Central Michigan | 24 | @ | Western Michigan | 31 | MAC | |||
| 11/19/2005 | Central Michigan | 31 | @ | Ball State | 24 | OT | MAC |