| 9/10/2005 | Akron | 24 | @ | Purdue | 49 | ||||
| 9/17/2005 | Purdue | 31 | @ | Arizona | 24 | ||||
| 9/24/2005 | Purdue | 35 | @ | Minnesota | 42 | 2 OT | B10 | ||
| 10/1/2005 | #5 Notre Dame | 49 | @ | Purdue | 28 | ||||
| 10/8/2005 | #25 Iowa | 34 | @ | Purdue | 17 | B10 | |||
| 10/15/2005 | Northwestern | 34 | @ | Purdue | 29 | B10 | |||
| 10/22/2005 | Purdue | 20 | @ | #20 Wisconsin | 31 | B10 | |||
| 10/29/2005 | Purdue | 15 | @ | #3 Penn State | 33 | B10 | |||
| 11/5/2005 | Michigan St | 21 | @ | Purdue | 28 | B10 | |||
| 11/12/2005 | Illinois | 3 | @ | Purdue | 37 | B10 | |||
| 11/19/2005 | Purdue | 41 | @ | Indiana | 14 | B10 |