| 9/3/2005 | Northern Illinois | 17 | @ | #20 Michigan | 33 | ||||
| 9/10/2005 | #5 Notre Dame | 17 | @ | #20 Michigan | 10 | ||||
| 9/17/2005 | Eastern Michigan | 0 | @ | #20 Michigan | 55 | ||||
| 9/24/2005 | #20 Michigan | 20 | @ | #20 Wisconsin | 23 | B10 | |||
| 10/1/2005 | #20 Michigan | 34 | @ | Michigan St | 31 | B10 | |||
| 10/8/2005 | Minnesota | 23 | @ | #20 Michigan | 20 | B10 | |||
| 10/15/2005 | #3 Penn State | 25 | @ | #20 Michigan | 27 | B10 | |||
| 10/22/2005 | #20 Michigan | 23 | @ | #25 Iowa | 20 | OT | B10 | ||
| 10/29/2005 | #20 Michigan | 38 | @ | Northwestern | 17 | B10 | |||
| 11/12/2005 | Indiana | 14 | @ | #20 Michigan | 41 | B10 | |||
| 11/19/2005 | #4 Ohio State | 25 | @ | #20 Michigan | 21 | B10 | |||
| 12/28/2005 | #20 Michigan | 28 | vs | Nebraska | 32 | Alamo |