| 9/1/2022 | Mars Hill | 7 | at | East Tennessee St (3-8) | 44 | at SoCon | ||
| 9/17/2022 | Catawba (1-10,0-9) | 7 | at | Mars Hill | 38 | |||
| 9/24/2022 | Mars Hill | 24 | at | Barton (4-7,3-6) | 18 | |||
| 9/29/2022 | Limestone (8-4,7-2) | 17 | at | Mars Hill | 14 | |||
| 10/8/2022 | Mars Hill | 33 | at | Erskine (2-9,0-9) | 13 | |||
| 10/15/2022 | Emory & Henry (5-6,4-5) | 14 | at | Mars Hill | 49 | |||
| 10/22/2022 | Carson-Newman (6-5,5-4) | 13 | at | Mars Hill | 44 | |||
| 10/29/2022 | Mars Hill | 20 | at | Virginia-Wise (2-9,1-8) | 16 | |||
| 11/5/2022 | Tusculum (8-3,6-3) | 27 | at | Mars Hill | 34 | |||
| 11/12/2022 | Mars Hill | 24 | at | Newberry (9-2,7-2) | 27 |
| vs Mars Hill | vs Other Opponents | Mars Hill compared to OOs | |
| Record: | 3-7 | 45-56 | |
| Points Scored: | 19.60 | 25.77 | 6.17 |
| Points Allowed: | 28.70 | 27.90 | 0.80 |
| Margin: | -9.10 | -2.13 | 6.97 |
| Total Points: | 48.30 | 53.67 | -5.37 |