D3
11 Jan 2022 16:14:08
| 9/3/2021 | Alvernia | 6 | at | Ursinus | 42 | | | MidAC |
| 9/4/2021 | Gettysburg | 7 | at | Bridgewater VA | 31 | | | @ ODC |
| McDaniel | 7 | at | Catholic | 40 | | | @ NEWMAC |
| Randolph-Macon | 31 | at | Dickinson | 21 | | | ODC |
| Grove City | 39 | at | Juniata | 14 | | | TPAC |
| Moravian | 10 | at | King's | 13 | | | @ MidAC |
| Franklin & Marshall | 14 | at | Lebanon Valley | 19 | | | @ MidAC |
| New Jersey | 0 | at | Muhlenberg | 41 | | | NJAC |
| Johns Hopkins | 53 | at | Stevenson | 18 | | | @ MidAC |
| Lycoming | 10 | at | Susquehanna | 44 | | | MidAC |
| 9/11/2021 | Muhlenberg | 34 | at | Dickinson | 13 | | | |
| Susquehanna | 30 | at | Franklin & Marshall | 28 | 5OT | | |
| Moravian | 16 | at | Gettysburg | 13 | OT | | |
| Ursinus | 21 | at | Johns Hopkins | 49 | | | |
| Juniata | 9 | at | McDaniel | 27 | | | |
| 9/18/2021 | Gettysburg | 3 | at | Dickinson | 34 | | | |
| McDaniel | 0 | at | Franklin & Marshall | 35 | | | |
| Johns Hopkins | 77 | at | Juniata | 0 | | | |
| Susquehanna | 44 | at | Moravian | 0 | | | |
| Ursinus | 42 | at | Muhlenberg | 35 | | | |
| 9/25/2021 | Juniata | 42 | at | Gettysburg | 48 | | | |
| Muhlenberg | 23 | at | McDaniel | 0 | | | |
| Johns Hopkins | 54 | at | Moravian | 6 | | | |
| Dickinson | 14 | at | Susquehanna | 31 | | | |
| Franklin & Marshall | 0 | at | Ursinus | 28 | | | |
| 10/2/2021 | McDaniel | 6 | at | Dickinson | 24 | | | |
| Muhlenberg | 54 | at | Gettysburg | 19 | | | |
| Franklin & Marshall | 10 | at | Johns Hopkins | 66 | | | |
| Moravian | 17 | at | Juniata | 24 | | | |
| Susquehanna | 62 | at | Ursinus | 23 | | | |
| 10/15/2021 | Johns Hopkins | 6 | at | Muhlenberg | 21 | | | |
| Gettysburg | 7 | at | Susquehanna | 47 | | | |
| 10/16/2021 | Juniata | 13 | at | Franklin & Marshall | 41 | | | |
| Ursinus | 18 | at | McDaniel | 14 | | | |
| Dickinson | 14 | at | Moravian | 21 | | | |
| 10/23/2021 | Franklin & Marshall | 17 | at | Dickinson | 13 | | | |
| Johns Hopkins | 50 | at | Gettysburg | 0 | | | |
| Ursinus | 34 | at | Moravian | 7 | | | |
| Juniata | 16 | at | Muhlenberg | 56 | | | |
| McDaniel | 16 | at | Susquehanna | 45 | | | |
| 10/30/2021 | Muhlenberg | 27 | at | Franklin & Marshall | 10 | | | |
| Susquehanna | 17 | at | Johns Hopkins | 38 | | | |
| Dickinson | 27 | at | Juniata | 10 | | | |
| Moravian | 37 | at | McDaniel | 31 | OT | | |
| Gettysburg | 21 | at | Ursinus | 42 | | | |
| 11/6/2021 | McDaniel | 7 | at | Gettysburg | 3 | | | |
| Dickinson | 17 | at | Johns Hopkins | 37 | | | |
| Franklin & Marshall | 14 | at | Moravian | 10 | | | |
| Muhlenberg | 52 | at | Susquehanna | 27 | | | |
| Juniata | 7 | at | Ursinus | 44 | | | |
| 11/13/2021 | Ursinus | 20 | at | Dickinson | 27 | OT | | |
| Gettysburg | 14 | at | Franklin & Marshall | 42 | | | |
| Susquehanna | 65 | at | Juniata | 0 | | | |
| Johns Hopkins | 48 | at | McDaniel | 7 | | | |
| Moravian | 0 | at | Muhlenberg | 55 | | | |
| 11/20/2021 | Stevenson | 28 | at | Franklin & Marshall | 42 | | | MidAC |
| Ursinus | 23 | at | Lycoming | 31 | | | @ MidAC |
| Framingham State | 0 | at | Muhlenberg | 45 | | | MSCAC |
| Johns Hopkins | 45 | at | Salisbury | 20 | | | @ NJAC |
| Widener | 21 | at | Susquehanna | 49 | | | MidAC |
| 11/27/2021 | Muhlenberg | 14 | at | Delaware Valley | 0 | | | @ MidAC |
| Johns Hopkins | 35 | at | Mount Union | 45 | | | @ OAC |
| 12/4/2021 | Muhlenberg | 29 | at | Mount Union | 35 | OT | | @ OAC |