| 9/4/2021 | Gettysburg | 7 | at | Bridgewater VA (4-6) | 31 | at ODC | ||
| 9/11/2021 | Moravian (3-7,3-6) | 16 | at | Gettysburg | 13 | OT | ||
| 9/18/2021 | Gettysburg | 3 | at | Dickinson (4-6,4-5) | 34 | |||
| 9/25/2021 | Juniata (1-9,1-8) | 42 | at | Gettysburg | 48 | |||
| 10/2/2021 | Muhlenberg (11-2,8-1) | 54 | at | Gettysburg | 19 | |||
| 10/15/2021 | Gettysburg | 7 | at | Susquehanna (9-2,7-2) | 47 | |||
| 10/23/2021 | Johns Hopkins (10-2,8-1) | 50 | at | Gettysburg | 0 | |||
| 10/30/2021 | Gettysburg | 21 | at | Ursinus (7-4,6-3) | 42 | |||
| 11/6/2021 | McDaniel (2-8,2-7) | 7 | at | Gettysburg | 3 | |||
| 11/13/2021 | Gettysburg | 14 | at | Franklin & Marshall (6-5,5-4) | 42 |
| vs Gettysburg | vs Other Opponents | Gettysburg compared to OOs | |
| Record: | 9-1 | 48-50 | |
| Points Scored: | 36.50 | 25.77 | -10.73 |
| Points Allowed: | 13.50 | 23.97 | -10.47 |
| Margin: | 23.00 | 1.80 | -21.20 |
| Total Points: | 50.00 | 49.74 | 0.26 |