| 9/4/2021 | Grove City (8-3) | 39 | at | Juniata | 14 | TPAC | ||
| 9/11/2021 | Juniata | 9 | at | McDaniel (2-8,2-7) | 27 | |||
| 9/18/2021 | Johns Hopkins (10-2,8-1) | 77 | at | Juniata | 0 | |||
| 9/25/2021 | Juniata | 42 | at | Gettysburg (1-9,1-8) | 48 | |||
| 10/2/2021 | Moravian (3-7,3-6) | 17 | at | Juniata | 24 | |||
| 10/16/2021 | Juniata | 13 | at | Franklin & Marshall (6-5,5-4) | 41 | |||
| 10/23/2021 | Juniata | 16 | at | Muhlenberg (11-2,8-1) | 56 | |||
| 10/30/2021 | Dickinson (4-6,4-5) | 27 | at | Juniata | 10 | |||
| 11/6/2021 | Juniata | 7 | at | Ursinus (7-4,6-3) | 44 | |||
| 11/13/2021 | Susquehanna (9-2,7-2) | 65 | at | Juniata | 0 |
| vs Juniata | vs Other Opponents | Juniata compared to OOs | |
| Record: | 9-1 | 52-47 | |
| Points Scored: | 44.10 | 26.76 | -17.34 |
| Points Allowed: | 13.50 | 22.81 | -9.31 |
| Margin: | 30.60 | 3.95 | -26.65 |
| Total Points: | 57.60 | 49.57 | 8.03 |