| 9/4/2021 | Lycoming | 10 | at | Susquehanna (9-2) | 44 | at Cen | ||
| 9/11/2021 | Lebanon Valley (5-5,4-5) | 6 | at | Lycoming | 31 | |||
| 9/18/2021 | Lycoming | 28 | at | King's (5-5,4-5) | 8 | |||
| 9/25/2021 | Lycoming | 29 | at | Stevenson (5-6,5-3) | 28 | |||
| 10/2/2021 | Delaware Valley (11-1,8-0) | 32 | at | Lycoming | 7 | |||
| 10/9/2021 | Misericordia (3-6,2-6) | 16 | at | Lycoming | 44 | |||
| 10/23/2021 | Albright (2-8,1-7) | 7 | at | Lycoming | 28 | |||
| 10/30/2021 | Wilkes (6-4,5-4) | 27 | at | Lycoming | 30 | |||
| 11/6/2021 | Lycoming | 0 | at | Widener (7-4,5-3) | 17 | |||
| 11/13/2021 | Lycoming | 48 | at | Alvernia (0-10,0-8) | 0 | |||
| 11/20/2021 | Ursinus (7-4) | 23 | at | Lycoming | 31 | Cen |
| vs Lycoming | vs Other Opponents | Lycoming compared to OOs | |
| Record: | 3-8 | 57-47 | |
| Points Scored: | 18.91 | 25.08 | 6.17 |
| Points Allowed: | 26.00 | 21.79 | 4.21 |
| Margin: | -7.09 | 3.29 | 10.38 |
| Total Points: | 44.91 | 46.87 | -1.96 |