| 9/4/2021 | McDaniel | 7 | at | Catholic (6-4) | 40 | at NEWMAC | ||
| 9/11/2021 | Juniata (1-9,1-8) | 9 | at | McDaniel | 27 | |||
| 9/18/2021 | McDaniel | 0 | at | Franklin & Marshall (6-5,5-4) | 35 | |||
| 9/25/2021 | Muhlenberg (11-2,8-1) | 23 | at | McDaniel | 0 | |||
| 10/2/2021 | McDaniel | 6 | at | Dickinson (4-6,4-5) | 24 | |||
| 10/16/2021 | Ursinus (7-4,6-3) | 18 | at | McDaniel | 14 | |||
| 10/23/2021 | McDaniel | 16 | at | Susquehanna (9-2,7-2) | 45 | |||
| 10/30/2021 | Moravian (3-7,3-6) | 37 | at | McDaniel | 31 | OT | ||
| 11/6/2021 | McDaniel | 7 | at | Gettysburg (1-9,1-8) | 3 | |||
| 11/13/2021 | Johns Hopkins (10-2,8-1) | 48 | at | McDaniel | 7 |
| vs McDaniel | vs Other Opponents | McDaniel compared to OOs | |
| Record: | 8-2 | 50-48 | |
| Points Scored: | 28.20 | 27.28 | -0.92 |
| Points Allowed: | 11.50 | 25.56 | -14.06 |
| Margin: | 16.70 | 1.72 | -14.98 |
| Total Points: | 39.70 | 52.84 | -13.14 |