| 9/4/2021 | Mount Union | 48 | at | Westminster PA (8-3) | 7 | at TPAC | ||
| 9/18/2021 | Baldwin-Wallace (8-2,7-2) | 7 | at | Mount Union | 31 | |||
| 9/25/2021 | Mount Union | 28 | at | John Carroll (7-3,7-2) | 14 | |||
| 10/2/2021 | Otterbein (1-9,1-8) | 0 | at | Mount Union | 55 | |||
| 10/9/2021 | Mount Union | 63 | at | Wilmington (2-7,2-6) | 0 | |||
| 10/16/2021 | Capital (2-8,1-8) | 0 | at | Mount Union | 63 | |||
| 10/23/2021 | Mount Union | 49 | at | Heidelberg (7-2,6-2) | 14 | |||
| 10/30/2021 | Ohio Northern (4-6,3-6) | 35 | at | Mount Union | 42 | |||
| 11/6/2021 | Muskingum (5-5,4-5) | 7 | at | Mount Union | 73 | |||
| 11/13/2021 | Mount Union | 37 | at | Marietta (4-6,4-5) | 7 | |||
| 11/20/2021 | Washington and Lee (8-3) | 0 | at | Mount Union | 52 | ODC | ||
| 11/27/2021 | Johns Hopkins (10-2) | 35 | at | Mount Union | 45 | Cen | ||
| 12/4/2021 | Muhlenberg (11-2) | 29 | at | Mount Union | 35 | OT | Cen | |
| 12/11/2021 | North Central (13-1) | 26 | at | Mount Union | 13 | D3 Semifinal | CCIW |
| vs Mount Union | vs Other Opponents | Mount Union compared to OOs | |
| Record: | 1-13 | 89-46 | |
| Points Scored: | 12.93 | 33.85 | 20.92 |
| Points Allowed: | 45.29 | 21.43 | 23.86 |
| Margin: | -32.36 | 12.42 | 44.78 |
| Total Points: | 58.22 | 55.28 | 2.94 |