| 9/3/2021 | Hobart (9-2) | 35 | at | Alfred | 3 | LL | ||
| 9/11/2021 | Alfred | 14 | at | Mt St Joseph (6-4) | 33 | at HCA | ||
| 9/18/2021 | Ithaca (8-2) | 34 | at | Alfred | 0 | LL | ||
| 9/25/2021 | Alfred | 10 | at | Kalamazoo (1-9) | 7 | at MIAA | ||
| 10/9/2021 | Hartwick (2-7,1-5) | 21 | at | Alfred | 24 | |||
| 10/16/2021 | Alfred | 38 | at | St John Fisher (4-6,3-4) | 35 | |||
| 10/23/2021 | Morrisville (2-8,2-5) | 16 | at | Alfred | 21 | |||
| 10/30/2021 | Alfred | 3 | at | Cortland (11-1,7-0) | 47 | |||
| 11/6/2021 | Utica (6-5,3-3) | 17 | at | Alfred | 24 | |||
| 11/13/2021 | Alfred | 0 | at | Brockport State (8-3,5-2) | 38 |
| vs Alfred | vs Other Opponents | Alfred compared to OOs | |
| Record: | 5-5 | 52-42 | |
| Points Scored: | 28.30 | 23.46 | -4.84 |
| Points Allowed: | 13.70 | 21.79 | -8.09 |
| Margin: | 14.60 | 1.67 | -12.93 |
| Total Points: | 42.00 | 45.25 | -3.25 |