| 9/4/2021 | Brockport State | 31 | at | Framingham State (8-3) | 0 | at MSCAC | ||
| 9/11/2021 | Ithaca (8-2) | 23 | at | Brockport State | 8 | LL | ||
| 9/18/2021 | Rochester (3-7) | 7 | at | Brockport State | 16 | LL | ||
| 10/2/2021 | Brockport State | 34 | at | St John Fisher (4-6,3-4) | 7 | |||
| 10/9/2021 | Brockport State | 10 | at | Cortland (11-1,7-0) | 31 | |||
| 10/16/2021 | Utica (6-5,3-3) | 14 | at | Brockport State | 26 | |||
| 10/23/2021 | Hartwick (2-7,1-5) | 14 | at | Brockport State | 41 | |||
| 10/30/2021 | Brockport State | 41 | at | Buffalo State (0-10,0-4) | 16 | |||
| 11/6/2021 | Brockport State | 7 | at | Morrisville (2-8,2-5) | 13 | |||
| 11/13/2021 | Alfred (5-5,4-2) | 0 | at | Brockport State | 38 | |||
| 11/20/2021 | Washington & Jefferson (8-3) | 7 | at | Brockport State | 20 | TPAC |
| vs Brockport State | vs Other Opponents | Brockport State compared to OOs | |
| Record: | 3-8 | 54-49 | |
| Points Scored: | 12.00 | 23.76 | 11.76 |
| Points Allowed: | 24.73 | 22.83 | 1.90 |
| Margin: | -12.73 | 0.93 | 13.66 |
| Total Points: | 36.73 | 46.59 | -9.86 |