| 9/4/2021 | Kalamazoo | 24 | at | Oberlin (1-9) | 17 | at NCA | ||
| 9/11/2021 | Kalamazoo | 13 | at | Central IA (12-1) | 69 | at ARC | ||
| 9/18/2021 | Bluffton (4-6) | 21 | at | Kalamazoo | 20 | HCA | ||
| 9/25/2021 | Alfred (5-5) | 10 | at | Kalamazoo | 7 | E8 | ||
| 10/2/2021 | Kalamazoo | 0 | at | Hope (8-2,5-1) | 67 | |||
| 10/9/2021 | Alma (5-5,1-5) | 28 | at | Kalamazoo | 3 | |||
| 10/16/2021 | Albion (9-2,5-1) | 49 | at | Kalamazoo | 0 | |||
| 10/23/2021 | Kalamazoo | 13 | at | Trine (6-4,4-2) | 47 | |||
| 10/30/2021 | Kalamazoo | 7 | at | Olivet (7-3,4-3) | 49 | |||
| 11/13/2021 | Adrian (5-5,4-3) | 33 | at | Kalamazoo | 21 |
| vs Kalamazoo | vs Other Opponents | Kalamazoo compared to OOs | |
| Record: | 9-1 | 53-41 | |
| Points Scored: | 39.00 | 29.47 | -9.53 |
| Points Allowed: | 10.80 | 25.71 | -14.91 |
| Margin: | 28.20 | 3.76 | -24.44 |
| Total Points: | 49.80 | 55.18 | -5.38 |