| 9/4/2021 | Utica | 39 | at | Alfred State (6-5) | 21 | at ECFC | ||
| 9/11/2021 | Utica | 27 | at | Kean (4-5) | 7 | at NJAC | ||
| 9/18/2021 | Western New England (7-4) | 28 | at | Utica | 37 | CCF | ||
| 9/25/2021 | Union NY (8-2) | 30 | at | Utica | 9 | LL | ||
| 10/2/2021 | Utica | 16 | at | Hartwick (2-7,1-5) | 10 | |||
| 10/16/2021 | Utica | 14 | at | Brockport State (8-3,5-2) | 26 | |||
| 10/23/2021 | Utica | 0 | at | Cortland (11-1,7-0) | 45 | |||
| 10/30/2021 | Morrisville (2-8,2-5) | 3 | at | Utica | 20 | |||
| 11/6/2021 | Utica | 17 | at | Alfred (5-5,4-2) | 24 | |||
| 11/13/2021 | St John Fisher (4-6,3-4) | 14 | at | Utica | 35 | |||
| 11/20/2021 | Utica | 7 | at | Grove City (8-3) | 49 | at TPAC |
| vs Utica | vs Other Opponents | Utica compared to OOs | |
| Record: | 5-6 | 60-43 | |
| Points Scored: | 23.36 | 25.42 | 2.06 |
| Points Allowed: | 20.09 | 21.50 | -1.41 |
| Margin: | 3.27 | 3.92 | 0.65 |
| Total Points: | 43.45 | 46.92 | -3.47 |