| 9/4/2021 | St John Fisher | 21 | at | Buffalo State (0-10,0-4) | 14 | |||
| 9/11/2021 | Framingham State (8-3) | 7 | at | St John Fisher | 38 | MSCAC | ||
| 9/18/2021 | Hobart (9-2) | 42 | at | St John Fisher | 21 | LL | ||
| 9/25/2021 | St John Fisher | 7 | at | Rensselaer (11-2) | 41 | at LL | ||
| 10/2/2021 | Brockport State (8-3,5-2) | 34 | at | St John Fisher | 7 | |||
| 10/9/2021 | St John Fisher | 28 | at | Morrisville (2-8,2-5) | 23 | |||
| 10/16/2021 | Alfred (5-5,4-2) | 38 | at | St John Fisher | 35 | |||
| 10/30/2021 | St John Fisher | 28 | at | Hartwick (2-7,1-5) | 7 | |||
| 11/6/2021 | Cortland (11-1,7-0) | 55 | at | St John Fisher | 3 | |||
| 11/13/2021 | St John Fisher | 14 | at | Utica (6-5,3-3) | 35 |
| vs St John Fisher | vs Other Opponents | St John Fisher compared to OOs | |
| Record: | 6-4 | 56-42 | |
| Points Scored: | 29.60 | 21.83 | -7.77 |
| Points Allowed: | 20.20 | 20.87 | -0.67 |
| Margin: | 9.40 | 0.96 | -8.44 |
| Total Points: | 49.80 | 42.70 | 7.10 |