| 9/4/2021 | Bridgewater State MA (6-4) | 20 | at | Ithaca | 52 | MSCAC | ||
| 9/11/2021 | Ithaca | 23 | at | Brockport State (8-3) | 8 | at E8 | ||
| 9/18/2021 | Ithaca | 34 | at | Alfred (5-5) | 0 | at E8 | ||
| 10/2/2021 | Hobart (9-2,3-2) | 21 | at | Ithaca | 28 | |||
| 10/9/2021 | Ithaca | 37 | at | Rochester (3-7,0-5) | 14 | |||
| 10/16/2021 | Ithaca | 17 | at | St Lawrence (5-5,1-4) | 0 | |||
| 10/23/2021 | Buffalo State (0-10) | 7 | at | Ithaca | 51 | E8 | ||
| 10/30/2021 | Ithaca | 11 | at | Rensselaer (11-2,4-1) | 14 | |||
| 11/6/2021 | Union NY (8-2,3-2) | 7 | at | Ithaca | 26 | |||
| 11/13/2021 | Ithaca | 27 | at | Cortland (11-1) | 28 | at E8 |
| vs Ithaca | vs Other Opponents | Ithaca compared to OOs | |
| Record: | 2-8 | 64-33 | |
| Points Scored: | 11.90 | 26.34 | 14.44 |
| Points Allowed: | 30.60 | 18.41 | 12.19 |
| Margin: | -18.70 | 7.93 | 26.63 |
| Total Points: | 42.50 | 44.75 | -2.25 |