| 9/4/2021 | Albion (9-2) | 36 | at | Mt St Joseph | 20 | MIAA | ||
| 9/11/2021 | Alfred (5-5) | 14 | at | Mt St Joseph | 33 | E8 | ||
| 9/18/2021 | Mt St Joseph | 30 | at | Trine (6-4) | 31 | OT | at MIAA | |
| 10/2/2021 | Mt St Joseph | 45 | at | Bluffton (4-6,3-4) | 27 | |||
| 10/9/2021 | Franklin (6-4,4-3) | 14 | at | Mt St Joseph | 28 | |||
| 10/16/2021 | Manchester (3-7,3-4) | 0 | at | Mt St Joseph | 28 | |||
| 10/23/2021 | Mt St Joseph | 13 | at | Defiance (1-9,1-6) | 14 | |||
| 10/30/2021 | Anderson (1-9,1-6) | 18 | at | Mt St Joseph | 35 | |||
| 11/6/2021 | Hanover (5-5,4-3) | 6 | at | Mt St Joseph | 23 | |||
| 11/13/2021 | Mt St Joseph | 21 | at | Rose-Hulman (8-3,7-0) | 58 |
| vs Mt St Joseph | vs Other Opponents | Mt St Joseph compared to OOs | |
| Record: | 4-6 | 44-48 | |
| Points Scored: | 21.80 | 22.92 | 1.12 |
| Points Allowed: | 27.60 | 26.09 | 1.51 |
| Margin: | -5.80 | -3.17 | 2.63 |
| Total Points: | 49.40 | 49.01 | 0.39 |