| 9/3/2021 | Hobart | 35 | at | Alfred | 3 | LL | ||
| 9/4/2021 | Utica | 39 | at | Alfred State | 21 | @ ECFC | ||
| St John Fisher | 21 | at | Buffalo State | 14 | ||||
| Brockport State | 31 | at | Framingham State | 0 | @ MSCAC | |||
| Morrisville | 14 | at | Union NY | 48 | @ LL | |||
| Cortland | 38 | at | Wittenberg | 16 | @ NCA | |||
| 9/11/2021 | Ithaca | 23 | at | Brockport State | 8 | LL | ||
| Alvernia | 14 | at | Hartwick | 23 | MidAC | |||
| Morrisville | 0 | at | Hobart | 41 | @ LL | |||
| Utica | 27 | at | Kean | 7 | @ NJAC | |||
| Alfred | 14 | at | Mt St Joseph | 33 | @ HCA | |||
| Cortland | 49 | at | New Jersey | 6 | @ NJAC | |||
| Framingham State | 7 | at | St John Fisher | 38 | MSCAC | |||
| 9/17/2021 | St Lawrence | 27 | at | Morrisville | 14 | LL | ||
| 9/18/2021 | Ithaca | 34 | at | Alfred | 0 | LL | ||
| Rochester | 7 | at | Brockport State | 16 | LL | |||
| Buffalo State | 9 | at | Cortland | 58 | ||||
| Hartwick | 7 | at | Curry | 14 | @ CCF | |||
| Hobart | 42 | at | St John Fisher | 21 | LL | |||
| Western New England | 28 | at | Utica | 37 | CCF | |||
| 9/25/2021 | Alfred | 10 | at | Kalamazoo | 7 | @ MIAA | ||
| Buffalo State | 10 | at | Morrisville | 41 | ||||
| St John Fisher | 7 | at | Rensselaer | 41 | @ LL | |||
| Union NY | 30 | at | Utica | 9 | LL | |||
| 10/2/2021 | Union NY | 30 | at | Buffalo State | 17 | LL | ||
| Utica | 16 | at | Hartwick | 10 | ||||
| Cortland | 58 | at | Morrisville | 7 | ||||
| Brockport State | 34 | at | St John Fisher | 7 | ||||
| 10/9/2021 | Hartwick | 21 | at | Alfred | 24 | |||
| Brockport State | 10 | at | Cortland | 31 | ||||
| St John Fisher | 28 | at | Morrisville | 23 | ||||
| Buffalo State | 16 | at | Rensselaer | 24 | @ LL | |||
| 10/16/2021 | Utica | 14 | at | Brockport State | 26 | |||
| Rochester | 14 | at | Buffalo State | 7 | LL | |||
| Cortland | 48 | at | Hartwick | 3 | ||||
| Alfred | 38 | at | St John Fisher | 35 | ||||
| 10/23/2021 | Morrisville | 16 | at | Alfred | 21 | |||
| Hartwick | 14 | at | Brockport State | 41 | ||||
| Utica | 0 | at | Cortland | 45 | ||||
| Buffalo State | 7 | at | Ithaca | 51 | @ LL | |||
| 10/30/2021 | Brockport State | 41 | at | Buffalo State | 16 | |||
| Alfred | 3 | at | Cortland | 47 | ||||
| St John Fisher | 28 | at | Hartwick | 7 | ||||
| Morrisville | 3 | at | Utica | 20 | ||||
| 11/6/2021 | Utica | 17 | at | Alfred | 24 | |||
| Rochester | 42 | at | Hartwick | 28 | LL | |||
| Buffalo State | 21 | at | Hobart | 45 | @ LL | |||
| Brockport State | 7 | at | Morrisville | 13 | ||||
| Cortland | 55 | at | St John Fisher | 3 | ||||
| 11/13/2021 | Alfred | 0 | at | Brockport State | 38 | |||
| St Lawrence | 41 | at | Buffalo State | 6 | LL | |||
| Ithaca | 27 | at | Cortland | 28 | LL | |||
| Morrisville | 7 | at | Hartwick | 14 | ||||
| St John Fisher | 14 | at | Utica | 35 | ||||
| 11/20/2021 | Washington & Jefferson | 7 | at | Brockport State | 20 | TPAC | ||
| Springfield | 21 | at | Cortland | 26 | NEWMAC | |||
| Utica | 7 | at | Grove City | 49 | @ TPAC | |||
| 11/27/2021 | Rensselaer | 21 | at | Cortland | 14 | LL |