| 9/3/2021 | Hobart | 35 | at | Alfred (5-5) | 3 | at E8 | ||
| 9/11/2021 | Morrisville (2-8) | 0 | at | Hobart | 41 | E8 | ||
| 9/18/2021 | Hobart | 42 | at | St John Fisher (4-6) | 21 | at E8 | ||
| 9/25/2021 | Keystone (0-10) | 14 | at | Hobart | 58 | ECFC | ||
| 10/2/2021 | Hobart | 21 | at | Ithaca (8-2,4-1) | 28 | |||
| 10/16/2021 | Rensselaer (11-2,4-1) | 9 | at | Hobart | 10 | |||
| 10/23/2021 | St Lawrence (5-5,1-4) | 13 | at | Hobart | 17 | |||
| 10/30/2021 | Hobart | 20 | at | Union NY (8-2,3-2) | 27 | OT | ||
| 11/6/2021 | Buffalo State (0-10) | 21 | at | Hobart | 45 | E8 | ||
| 11/13/2021 | Hobart | 31 | at | Rochester (3-7,0-5) | 0 | |||
| 11/20/2021 | Hobart | 21 | at | Westminster PA (8-3) | 3 | at TPAC |
| vs Hobart | vs Other Opponents | Hobart compared to OOs | |
| Record: | 2-9 | 52-51 | |
| Points Scored: | 12.64 | 22.05 | 9.41 |
| Points Allowed: | 31.00 | 23.65 | 7.35 |
| Margin: | -18.36 | -1.60 | 16.76 |
| Total Points: | 43.64 | 45.70 | -2.06 |