| 9/4/2021 | Alderson-Broaddus (1-10) | 3 | at | Mercyhurst | 18 | MtnE | ||
| 9/11/2021 | West Chester (6-5,6-4) | 56 | at | Mercyhurst | 10 | |||
| 9/18/2021 | Mercyhurst | 7 | at | East Stroudsburg (5-6,4-6) | 17 | |||
| 9/25/2021 | Indiana PA (7-3,7-3) | 48 | at | Mercyhurst | 13 | |||
| 10/2/2021 | Mercyhurst | 0 | at | California PA (9-1,8-1) | 37 | |||
| 10/9/2021 | Seton Hill (5-6,4-6) | 19 | at | Mercyhurst | 17 | |||
| 10/16/2021 | Mercyhurst | 27 | at | Edinboro (4-6,4-6) | 20 | OT | ||
| 10/23/2021 | Slippery Rock (9-3,8-2) | 20 | at | Mercyhurst | 17 | |||
| 10/30/2021 | Mercyhurst | 38 | at | Clarion (0-10,0-9) | 20 | |||
| 11/6/2021 | Gannon (5-6,4-6) | 13 | at | Mercyhurst | 24 | |||
| 11/13/2021 | Mercyhurst | 13 | at | Shippensburg (9-2,8-2) | 17 |
| vs Mercyhurst | vs Other Opponents | Mercyhurst compared to OOs | |
| Record: | 7-4 | 53-54 | |
| Points Scored: | 24.55 | 26.14 | 1.59 |
| Points Allowed: | 16.73 | 26.50 | -9.77 |
| Margin: | 7.82 | -0.36 | -8.18 |
| Total Points: | 41.28 | 52.64 | -11.36 |