| 9/4/2021 | Truman State | 31 | at | Davenport (3-8) | 14 | at GLIAC | ||
| 9/11/2021 | Truman State | 27 | at | Wayne State MI (2-9) | 9 | at GLIAC | ||
| 9/18/2021 | Hillsdale (6-6) | 24 | at | Truman State | 38 | GMAC | ||
| 9/25/2021 | Truman State | 38 | at | Tiffin (8-3) | 35 | at GMAC | ||
| 10/2/2021 | Lindenwood (9-3) | 31 | at | Truman State | 21 | MAIAA | ||
| 10/9/2021 | Truman State | 38 | at | Missouri S&T (6-5,4-2) | 21 | |||
| 10/16/2021 | Truman State | 21 | at | Southwest Baptist (4-7,3-3) | 27 | |||
| 10/23/2021 | William Jewell (0-11,0-6) | 0 | at | Truman State | 52 | |||
| 10/30/2021 | Quincy (4-7,2-4) | 28 | at | Truman State | 49 | |||
| 11/6/2021 | Truman State | 44 | at | McKendree (4-7,3-3) | 13 | |||
| 11/13/2021 | Indianapolis (7-4,5-1) | 13 | at | Truman State | 10 | |||
| 12/4/2021 | Truman State | 34 | at | Hillsdale (6-6) | 17 | at GMAC |
| vs Truman State | vs Other Opponents | Truman State compared to OOs | |
| Record: | 3-9 | 56-65 | |
| Points Scored: | 19.33 | 28.57 | 9.24 |
| Points Allowed: | 33.58 | 30.60 | 2.98 |
| Margin: | -14.25 | -2.03 | 12.22 |
| Total Points: | 52.91 | 59.17 | -6.26 |