| 9/4/2021 | Tiffin | 34 | at | Marian IN (9-3) | 10 | at MSFA | ||
| 9/11/2021 | Northwood (1-9) | 6 | at | Tiffin | 40 | GLIAC | ||
| 9/18/2021 | Tiffin | 20 | at | Indianapolis (7-4) | 17 | at GLV | ||
| 9/25/2021 | Truman State (9-3) | 38 | at | Tiffin | 35 | GLV | ||
| 10/2/2021 | Hillsdale (6-6,5-2) | 24 | at | Tiffin | 21 | |||
| 10/9/2021 | Tiffin | 35 | at | Lake Erie (5-6,2-5) | 17 | |||
| 10/16/2021 | Ashland (5-5,4-3) | 21 | at | Tiffin | 27 | |||
| 10/23/2021 | Tiffin | 34 | at | Kentucky Wesleyan (3-8,1-6) | 28 | |||
| 10/30/2021 | Ohio Dominican (7-4,4-3) | 21 | at | Tiffin | 34 | |||
| 11/6/2021 | Tiffin | 56 | at | Walsh (2-9,1-6) | 16 | |||
| 11/13/2021 | Tiffin | 21 | at | Findlay (8-4,6-1) | 26 |
| vs Tiffin | vs Other Opponents | Tiffin compared to OOs | |
| Record: | 3-8 | 59-53 | |
| Points Scored: | 20.36 | 27.54 | 7.18 |
| Points Allowed: | 32.45 | 24.08 | 8.37 |
| Margin: | -12.09 | 3.46 | 15.55 |
| Total Points: | 52.81 | 51.62 | 1.19 |