| 9/4/2021 | Midwestern State (7-3) | 48 | at | Quincy | 27 | LSC | ||
| 9/11/2021 | Iowa Wesleyan (2-9) | 27 | at | Quincy | 59 | NAIAInd (NAIA) | ||
| 9/18/2021 | Walsh (2-9) | 17 | at | Quincy | 38 | GMAC | ||
| 9/25/2021 | Quincy | 23 | at | Ashland (5-5) | 63 | at GMAC | ||
| 10/2/2021 | Missouri S&T (6-5,4-2) | 28 | at | Quincy | 31 | |||
| 10/9/2021 | Quincy | 28 | at | Lindenwood (9-3) | 33 | at MAIAA | ||
| 10/16/2021 | McKendree (4-7,3-3) | 51 | at | Quincy | 48 | |||
| 10/23/2021 | Indianapolis (7-4,5-1) | 70 | at | Quincy | 21 | |||
| 10/30/2021 | Quincy | 28 | at | Truman State (9-3,4-2) | 49 | |||
| 11/6/2021 | Southwest Baptist (4-7,3-3) | 47 | at | Quincy | 31 | |||
| 11/13/2021 | Quincy | 51 | at | William Jewell (0-11,0-6) | 17 |
| vs Quincy | vs Other Opponents | Quincy compared to OOs | |
| Record: | 7-4 | 48-62 | |
| Points Scored: | 40.91 | 26.84 | -14.07 |
| Points Allowed: | 35.00 | 29.82 | 5.18 |
| Margin: | 5.91 | -2.98 | -8.89 |
| Total Points: | 75.91 | 56.66 | 19.25 |