| 9/2/2021 | Missouri S&T | 31 | at | South Dakota Tech (6-5) | 34 | at RMAC | ||
| 9/11/2021 | Arkansas Baptist (0-7) | 0 | at | Missouri S&T | 71 | None (Unk?) | ||
| 9/18/2021 | Wayne State MI (2-9) | 45 | at | Missouri S&T | 51 | OT | GLIAC | |
| 9/25/2021 | Missouri S&T | 31 | at | Hillsdale (6-6) | 38 | at GMAC | ||
| 10/2/2021 | Missouri S&T | 28 | at | Quincy (4-7,2-4) | 31 | |||
| 10/9/2021 | Truman State (9-3,4-2) | 38 | at | Missouri S&T | 21 | |||
| 10/16/2021 | William Jewell (0-11,0-6) | 16 | at | Missouri S&T | 37 | |||
| 10/23/2021 | Missouri S&T | 37 | at | McKendree (4-7,3-3) | 31 | |||
| 10/30/2021 | Indianapolis (7-4,5-1) | 28 | at | Missouri S&T | 31 | |||
| 11/6/2021 | Lindenwood (9-3) | 43 | at | Missouri S&T | 16 | MAIAA | ||
| 11/13/2021 | Missouri S&T | 42 | at | Southwest Baptist (4-7,3-3) | 41 |
| vs Missouri S&T | vs Other Opponents | Missouri S&T compared to OOs | |
| Record: | 5-6 | 46-63 | |
| Points Scored: | 31.36 | 27.28 | -4.08 |
| Points Allowed: | 36.00 | 32.18 | 3.82 |
| Margin: | -4.64 | -4.90 | -0.26 |
| Total Points: | 67.36 | 59.46 | 7.90 |