| 9/4/2021 | Indianapolis | 34 | at | St Xavier (7-3) | 10 | at MSFA | ||
| 9/11/2021 | Indianapolis | 35 | at | Hillsdale (6-6) | 31 | at GMAC | ||
| 9/18/2021 | Tiffin (8-3) | 20 | at | Indianapolis | 17 | GMAC | ||
| 9/25/2021 | Ohio Dominican (7-4) | 19 | at | Indianapolis | 16 | GMAC | ||
| 10/2/2021 | Indianapolis | 77 | at | Southwest Baptist (4-7,3-3) | 10 | |||
| 10/9/2021 | McKendree (4-7,3-3) | 28 | at | Indianapolis | 57 | |||
| 10/16/2021 | Lindenwood (9-3) | 28 | at | Indianapolis | 20 | MAIAA | ||
| 10/23/2021 | Indianapolis | 70 | at | Quincy (4-7,2-4) | 21 | |||
| 10/30/2021 | Indianapolis | 28 | at | Missouri S&T (6-5,4-2) | 31 | |||
| 11/6/2021 | William Jewell (0-11,0-6) | 14 | at | Indianapolis | 45 | |||
| 11/13/2021 | Indianapolis | 13 | at | Truman State (9-3,4-2) | 10 |
| vs Indianapolis | vs Other Opponents | Indianapolis compared to OOs | |
| Record: | 4-7 | 60-52 | |
| Points Scored: | 20.18 | 30.65 | 10.47 |
| Points Allowed: | 37.45 | 28.64 | 8.81 |
| Margin: | -17.27 | 2.01 | 19.28 |
| Total Points: | 57.63 | 59.29 | -1.66 |