| 9/4/2021 | Northern Michigan (4-7) | 27 | at | McKendree | 20 | GLIAC | ||
| 9/11/2021 | McKendree | 17 | at | Delta State (5-6) | 45 | at GSC | ||
| 9/18/2021 | Lake Erie (5-6) | 17 | at | McKendree | 10 | GMAC | ||
| 9/25/2021 | McKendree | 24 | at | Walsh (2-9) | 10 | at GMAC | ||
| 10/2/2021 | William Jewell (0-11,0-6) | 10 | at | McKendree | 52 | |||
| 10/9/2021 | McKendree | 28 | at | Indianapolis (7-4,5-1) | 57 | |||
| 10/16/2021 | McKendree | 51 | at | Quincy (4-7,2-4) | 48 | |||
| 10/23/2021 | Missouri S&T (6-5,4-2) | 37 | at | McKendree | 31 | |||
| 10/30/2021 | McKendree | 45 | at | Southwest Baptist (4-7,3-3) | 42 | |||
| 11/6/2021 | Truman State (9-3,4-2) | 44 | at | McKendree | 13 | |||
| 11/13/2021 | McKendree | 30 | at | Lindenwood (9-3) | 45 | at MAIAA |
| vs McKendree | vs Other Opponents | McKendree compared to OOs | |
| Record: | 7-4 | 48-64 | |
| Points Scored: | 34.73 | 26.83 | -7.90 |
| Points Allowed: | 29.18 | 30.42 | -1.24 |
| Margin: | 5.55 | -3.59 | -9.14 |
| Total Points: | 63.91 | 57.25 | 6.66 |