| 9/2/2021 | Angelo State (11-3) | 40 | at | Lindenwood | 20 | LSC | ||
| 9/11/2021 | Lindenwood | 7 | at | South Dakota State (11-4) | 52 | at MVC | ||
| 9/18/2021 | Kentucky Wesleyan (3-8) | 34 | at | Lindenwood | 56 | GMAC | ||
| 9/25/2021 | Lindenwood | 28 | at | Findlay (8-4) | 16 | at GMAC | ||
| 10/2/2021 | Lindenwood | 31 | at | Truman State (9-3) | 21 | at GLV | ||
| 10/9/2021 | Quincy (4-7) | 28 | at | Lindenwood | 33 | GLV | ||
| 10/16/2021 | Lindenwood | 28 | at | Indianapolis (7-4) | 20 | at GLV | ||
| 10/23/2021 | Southwest Baptist (4-7) | 24 | at | Lindenwood | 48 | GLV | ||
| 10/30/2021 | Lindenwood | 53 | at | William Jewell (0-11) | 10 | at GLV | ||
| 11/6/2021 | Lindenwood | 43 | at | Missouri S&T (6-5) | 16 | at GLV | ||
| 11/13/2021 | McKendree (4-7) | 30 | at | Lindenwood | 45 | GLV | ||
| 11/20/2021 | Lindenwood | 3 | at | Grand Valley State (10-2) | 20 | at GLIAC |
| vs Lindenwood | vs Other Opponents | Lindenwood compared to OOs | |
| Record: | 3-9 | 74-56 | |
| Points Scored: | 25.92 | 32.48 | 6.56 |
| Points Allowed: | 32.92 | 27.25 | 5.67 |
| Margin: | -7.00 | 5.23 | 12.23 |
| Total Points: | 58.84 | 59.73 | -0.89 |