| 9/4/2021 | Hillsdale | 10 | at | Michigan Tech (6-4) | 14 | at GLIAC | ||
| 9/11/2021 | Indianapolis (7-4) | 35 | at | Hillsdale | 31 | GLV | ||
| 9/18/2021 | Hillsdale | 24 | at | Truman State (9-3) | 38 | at GLV | ||
| 9/25/2021 | Missouri S&T (6-5) | 31 | at | Hillsdale | 38 | GLV | ||
| 10/2/2021 | Hillsdale | 24 | at | Tiffin (8-3,5-2) | 21 | |||
| 10/9/2021 | Walsh (2-9,1-6) | 3 | at | Hillsdale | 20 | |||
| 10/16/2021 | Lake Erie (5-6,2-5) | 33 | at | Hillsdale | 14 | |||
| 10/23/2021 | Hillsdale | 34 | at | Findlay (8-4,6-1) | 29 | |||
| 10/30/2021 | Hillsdale | 17 | at | Ashland (5-5,4-3) | 28 | |||
| 11/6/2021 | Kentucky Wesleyan (3-8,1-6) | 12 | at | Hillsdale | 31 | |||
| 11/13/2021 | Ohio Dominican (7-4,4-3) | 17 | at | Hillsdale | 21 | |||
| 12/4/2021 | Truman State (9-3) | 34 | at | Hillsdale | 17 | GLV |
| vs Hillsdale | vs Other Opponents | Hillsdale compared to OOs | |
| Record: | 6-6 | 67-52 | |
| Points Scored: | 24.58 | 29.31 | 4.73 |
| Points Allowed: | 23.42 | 24.29 | -0.87 |
| Margin: | 1.16 | 5.02 | 3.86 |
| Total Points: | 48.00 | 53.60 | -5.60 |