| 9/4/2021 | Truman State (9-3) | 31 | at | Davenport | 14 | GLV | ||
| 9/11/2021 | Davenport | 10 | at | Walsh (2-9) | 6 | at GMAC | ||
| 9/18/2021 | Davenport | 14 | at | Northern Michigan (4-7,3-6) | 20 | |||
| 9/25/2021 | Davenport | 0 | at | Ferris State (14-0,9-0) | 38 | |||
| 10/2/2021 | Davenport | 7 | at | Michigan Tech (6-4,5-3) | 31 | |||
| 10/9/2021 | Northern Michigan (4-7,3-6) | 13 | at | Davenport | 18 | |||
| 10/16/2021 | Wayne State MI (2-9,2-6) | 16 | at | Davenport | 3 | |||
| 10/23/2021 | Davenport | 21 | at | Northwood (1-9,1-7) | 14 | |||
| 10/30/2021 | Saginaw Valley State (7-4,5-3) | 24 | at | Davenport | 3 | |||
| 11/6/2021 | Ferris State (14-0,9-0) | 50 | at | Davenport | 14 | |||
| 11/13/2021 | Davenport | 0 | at | Grand Valley State (10-2,7-2) | 42 |
| vs Davenport | vs Other Opponents | Davenport compared to OOs | |
| Record: | 8-3 | 62-50 | |
| Points Scored: | 25.91 | 30.77 | 4.86 |
| Points Allowed: | 9.45 | 26.47 | -17.02 |
| Margin: | 16.46 | 4.30 | -12.16 |
| Total Points: | 35.36 | 57.24 | -21.88 |