| 9/2/2021 | William Jewell | 3 | at | Colorado Mesa (8-2) | 40 | at RMAC | ||
| 9/11/2021 | Black Hills State (4-7) | 31 | at | William Jewell | 21 | RMAC | ||
| 9/18/2021 | Ohio Dominican (7-4) | 35 | at | William Jewell | 25 | GMAC | ||
| 9/25/2021 | William Jewell | 21 | at | Kentucky Wesleyan (3-8) | 41 | at GMAC | ||
| 10/2/2021 | William Jewell | 10 | at | McKendree (4-7,3-3) | 52 | |||
| 10/9/2021 | Southwest Baptist (4-7,3-3) | 55 | at | William Jewell | 10 | |||
| 10/16/2021 | William Jewell | 16 | at | Missouri S&T (6-5,4-2) | 37 | |||
| 10/23/2021 | William Jewell | 0 | at | Truman State (9-3,4-2) | 52 | |||
| 10/30/2021 | Lindenwood (9-3) | 53 | at | William Jewell | 10 | MAIAA | ||
| 11/6/2021 | William Jewell | 14 | at | Indianapolis (7-4,5-1) | 45 | |||
| 11/13/2021 | Quincy (4-7,2-4) | 51 | at | William Jewell | 17 |
| vs William Jewell | vs Other Opponents | William Jewell compared to OOs | |
| Record: | 11-0 | 54-57 | |
| Points Scored: | 44.73 | 29.83 | -14.90 |
| Points Allowed: | 13.36 | 29.75 | -16.39 |
| Margin: | 31.37 | 0.08 | -31.29 |
| Total Points: | 58.09 | 59.58 | -1.49 |