| 9/2/2021 | Gannon | 28 | at | Northwood (1-9) | 21 | OT | at GLIAC | |
| 9/11/2021 | Shepherd (13-2,10-1) | 56 | at | Gannon | 26 | |||
| 9/18/2021 | Gannon | 27 | at | Bloomsburg (3-8,3-7) | 31 | |||
| 9/25/2021 | Clarion (0-10,0-9) | 21 | at | Gannon | 56 | |||
| 10/2/2021 | Gannon | 23 | at | Indiana PA (7-3,7-3) | 28 | |||
| 10/9/2021 | California PA (9-1,8-1) | 38 | at | Gannon | 17 | |||
| 10/16/2021 | Gannon | 14 | at | Seton Hill (5-6,4-6) | 10 | |||
| 10/23/2021 | Edinboro (4-6,4-6) | 18 | at | Gannon | 21 | |||
| 10/30/2021 | Slippery Rock (9-3,8-2) | 63 | at | Gannon | 21 | |||
| 11/6/2021 | Gannon | 13 | at | Mercyhurst (4-7,3-7) | 24 | |||
| 11/13/2021 | Gannon | 13 | at | East Stroudsburg (5-6,4-6) | 10 |
| vs Gannon | vs Other Opponents | Gannon compared to OOs | |
| Record: | 6-5 | 54-56 | |
| Points Scored: | 29.09 | 26.04 | -3.05 |
| Points Allowed: | 23.55 | 26.40 | -2.85 |
| Margin: | 5.54 | -0.36 | -5.90 |
| Total Points: | 52.64 | 52.44 | 0.20 |