| 9/4/2021 | Fresno State (10-3) | 24 | at | Oregon | 31 | | | MW |
| 9/11/2021 | Oregon | 35 | at | Ohio State (11-2) | 28 | | | at B10 |
| 9/18/2021 | Stony Brook (5-6) | 7 | at | Oregon | 48 | | | CAAF (1AA) |
| 9/25/2021 | Arizona (1-11,1-8) | 19 | at | Oregon | 41 | | | |
| 10/2/2021 | Oregon | 24 | at | Stanford (3-9,2-7) | 31 | OT | | |
| 10/15/2021 | California (5-7,4-5) | 17 | at | Oregon | 24 | | | |
| 10/23/2021 | Oregon | 34 | at | UCLA (8-4,6-3) | 31 | | | |
| 10/30/2021 | Colorado (4-8,3-6) | 29 | at | Oregon | 52 | | | |
| 11/6/2021 | Oregon | 26 | at | Washington (4-8,3-6) | 16 | | | |
| 11/13/2021 | Washington State (7-6,6-3) | 24 | at | Oregon | 38 | | | |
| 11/20/2021 | Oregon | 7 | at | Utah (10-4,9-1) | 38 | | | |
| 11/27/2021 | Oregon State (7-6,5-4) | 29 | at | Oregon | 38 | | | |
| 12/3/2021 | Oregon | 10 | vs | Utah (10-4,9-1) | 38 | | P12 Championship - Las Vegas NV | |
| 12/29/2021 | Oregon | 32 | vs | Oklahoma (11-2) | 47 | | Alamo Bowl - San Antonio TX | vs B12 |