| 9/4/2021 | Nevada (8-5) | 22 | at | California | 17 | MW | ||
| 9/11/2021 | California | 32 | at | TCU (5-7) | 34 | at B12 | ||
| 9/18/2021 | Sacramento State (9-3) | 30 | at | California | 42 | BSky (1AA) | ||
| 9/25/2021 | California | 24 | at | Washington (4-8,3-6) | 31 | OT | ||
| 10/2/2021 | Washington State (7-6,6-3) | 21 | at | California | 6 | |||
| 10/15/2021 | California | 17 | at | Oregon (10-4,7-3) | 24 | |||
| 10/23/2021 | Colorado (4-8,3-6) | 3 | at | California | 26 | |||
| 10/30/2021 | Oregon State (7-6,5-4) | 25 | at | California | 39 | |||
| 11/6/2021 | California | 3 | at | Arizona (1-11,1-8) | 10 | |||
| 11/20/2021 | California | 41 | at | Stanford (3-9,2-7) | 11 | |||
| 11/27/2021 | California | 14 | at | UCLA (8-4,6-3) | 42 | |||
| 12/4/2021 | Southern California (4-8,3-6) | 14 | at | California | 24 |
| vs California | vs Other Opponents | California compared to OOs | |
| Record: | 7-5 | 63-74 | |
| Points Scored: | 22.25 | 27.95 | 5.70 |
| Points Allowed: | 23.75 | 27.71 | -3.96 |
| Margin: | -1.50 | 0.24 | 1.74 |
| Total Points: | 46.00 | 55.66 | -9.66 |