| 9/4/2021 | Oregon State | 21 | at | Purdue (9-4) | 30 | at B10 | ||
| 9/11/2021 | Hawaii (6-7) | 27 | at | Oregon State | 45 | MW | ||
| 9/18/2021 | Idaho (4-7) | 0 | at | Oregon State | 42 | BSky (1AA) | ||
| 9/25/2021 | Oregon State | 45 | at | Southern California (4-8,3-6) | 27 | |||
| 10/2/2021 | Washington (4-8,3-6) | 24 | at | Oregon State | 27 | |||
| 10/9/2021 | Oregon State | 24 | at | Washington State (7-6,6-3) | 31 | |||
| 10/23/2021 | Utah (10-4,9-1) | 34 | at | Oregon State | 42 | |||
| 10/30/2021 | Oregon State | 25 | at | California (5-7,4-5) | 39 | |||
| 11/6/2021 | Oregon State | 34 | at | Colorado (4-8,3-6) | 37 | 2OT | ||
| 11/13/2021 | Stanford (3-9,2-7) | 14 | at | Oregon State | 35 | |||
| 11/20/2021 | Arizona State (8-5,6-3) | 10 | at | Oregon State | 24 | |||
| 11/27/2021 | Oregon State | 29 | at | Oregon (10-4,7-3) | 38 | |||
| 12/18/2021 | Utah State (11-3) | 24 | vs | Oregon State | 13 | LA Bowl - Inglewood CA | MW |
| vs Oregon State | vs Other Opponents | Oregon State compared to OOs | |
| Record: | 6-7 | 79-73 | |
| Points Scored: | 25.77 | 27.54 | 1.77 |
| Points Allowed: | 31.23 | 25.60 | 5.63 |
| Margin: | -5.46 | 1.94 | 7.40 |
| Total Points: | 57.00 | 53.14 | 3.86 |