| 9/4/2021 | BYU | 24 | vs | Arizona (1-11) | 16 | Las Vegas NV | vs P12 | |
| 9/11/2021 | Utah (10-4) | 17 | at | BYU | 26 | P12 | ||
| 9/18/2021 | Arizona State (8-5) | 17 | at | BYU | 27 | P12 | ||
| 9/25/2021 | South Florida (2-10) | 27 | at | BYU | 35 | AAC | ||
| 10/1/2021 | BYU | 34 | at | Utah State (11-3) | 20 | at MW | ||
| 10/9/2021 | Boise State (7-5) | 26 | at | BYU | 17 | MW | ||
| 10/16/2021 | BYU | 24 | at | Baylor (12-2) | 38 | at B12 | ||
| 10/23/2021 | BYU | 21 | at | Washington State (7-6) | 19 | at P12 | ||
| 10/30/2021 | Virginia (6-6) | 49 | at | BYU | 66 | ACC | ||
| 11/6/2021 | Idaho State (1-10) | 14 | at | BYU | 59 | BSky (1AA) | ||
| 11/20/2021 | BYU | 34 | at | Georgia Southern (3-9) | 17 | at SBC | ||
| 11/27/2021 | BYU | 35 | at | Southern California (4-8) | 31 | at P12 | ||
| 12/18/2021 | UAB (9-4) | 31 | vs | BYU | 28 | Independence Bowl - Shreveport LA | CUSA |
| vs BYU | vs Other Opponents | BYU compared to OOs | |
| Record: | 3-10 | 78-73 | |
| Points Scored: | 24.77 | 27.83 | 3.06 |
| Points Allowed: | 33.08 | 25.88 | 7.20 |
| Margin: | -8.31 | 1.95 | 10.26 |
| Total Points: | 57.85 | 53.71 | 4.14 |