| 9/4/2021 | Baylor (12-2) | 29 | at | Texas State | 20 | B12 | ||
| 9/11/2021 | Texas State | 23 | at | Florida Intl (1-11) | 17 | OT | at CUSA | |
| 9/18/2021 | Incarnate Word (10-3) | 42 | at | Texas State | 34 | SLC (1AA) | ||
| 9/25/2021 | Texas State | 21 | at | Eastern Michigan (7-6) | 59 | at MAC | ||
| 10/9/2021 | South Alabama (5-7,2-6) | 31 | at | Texas State | 33 | 4OT | ||
| 10/16/2021 | Troy (5-7,3-5) | 31 | at | Texas State | 28 | |||
| 10/23/2021 | Texas State | 16 | at | Georgia State (8-5,6-2) | 28 | |||
| 10/30/2021 | Texas State | 0 | at | UL Lafayette (13-1,9-0) | 45 | |||
| 11/6/2021 | UL Monroe (4-8,2-6) | 19 | at | Texas State | 27 | |||
| 11/13/2021 | Georgia Southern (3-9,2-6) | 38 | at | Texas State | 30 | |||
| 11/20/2021 | Texas State | 21 | at | Coastal Carolina (11-2,6-2) | 35 | |||
| 11/27/2021 | Texas State | 24 | at | Arkansas State (2-10,1-7) | 22 |
| vs Texas State | vs Other Opponents | Texas State compared to OOs | |
| Record: | 8-4 | 73-67 | |
| Points Scored: | 33.00 | 27.85 | -5.15 |
| Points Allowed: | 23.08 | 28.28 | -5.20 |
| Margin: | 9.92 | -0.43 | -10.35 |
| Total Points: | 56.08 | 56.13 | -0.05 |