| 9/2/2021 | Eastern Washington (10-3) | 35 | at | UNLV | 33 | 2OT | BSky (1AA) | |
| 9/11/2021 | UNLV | 10 | at | Arizona State (8-5) | 37 | at P12 | ||
| 9/18/2021 | Iowa State (7-6) | 48 | at | UNLV | 3 | B12 | ||
| 9/24/2021 | UNLV | 30 | at | Fresno State (10-3,6-2) | 38 | |||
| 10/2/2021 | UNLV | 17 | at | Texas-San Antonio (12-2) | 24 | at CUSA | ||
| 10/16/2021 | Utah State (11-3,7-2) | 28 | at | UNLV | 24 | |||
| 10/21/2021 | San Jose State (5-7,3-5) | 27 | at | UNLV | 20 | |||
| 10/29/2021 | UNLV | 20 | at | Nevada (8-5,5-3) | 51 | |||
| 11/6/2021 | UNLV | 31 | at | New Mexico (3-9,1-7) | 17 | |||
| 11/13/2021 | Hawaii (6-7,3-5) | 13 | at | UNLV | 27 | |||
| 11/19/2021 | San Diego State (12-2,7-2) | 28 | at | UNLV | 20 | |||
| 11/26/2021 | UNLV | 14 | at | Air Force (10-3,6-2) | 48 |
| vs UNLV | vs Other Opponents | UNLV compared to OOs | |
| Record: | 10-2 | 92-53 | |
| Points Scored: | 32.83 | 30.14 | -2.69 |
| Points Allowed: | 20.75 | 24.49 | -3.74 |
| Margin: | 12.08 | 5.65 | -6.43 |
| Total Points: | 53.58 | 54.63 | -1.05 |