| 9/4/2021 | Western Michigan | 14 | at | Michigan (12-2) | 47 | at B10 | ||
| 9/11/2021 | Illinois State (4-7) | 0 | at | Western Michigan | 28 | MVC (1AA) | ||
| 9/18/2021 | Western Michigan | 44 | at | Pittsburgh (11-3) | 41 | at ACC | ||
| 9/25/2021 | San Jose State (5-7) | 3 | at | Western Michigan | 23 | MW | ||
| 10/2/2021 | Western Michigan | 24 | at | Buffalo (4-8,2-6) | 17 | |||
| 10/9/2021 | Ball State (6-7,4-4) | 45 | at | Western Michigan | 20 | |||
| 10/16/2021 | Kent State (7-7,6-3) | 31 | at | Western Michigan | 64 | |||
| 10/23/2021 | Western Michigan | 15 | at | Toledo (7-6,5-3) | 34 | |||
| 11/3/2021 | Central Michigan (9-4,6-2) | 42 | at | Western Michigan | 30 | |||
| 11/9/2021 | Akron (2-10,1-7) | 40 | at | Western Michigan | 45 | |||
| 11/16/2021 | Western Michigan | 21 | at | Eastern Michigan (7-6,4-4) | 22 | |||
| 11/23/2021 | Western Michigan | 42 | at | Northern Illinois (9-5,7-2) | 21 | |||
| 12/27/2021 | Western Michigan | 52 | vs | Nevada (8-5) | 24 | Quick Lane Bowl - Detroit MI | vs MW |
| vs Western Michigan | vs Other Opponents | Western Michigan compared to OOs | |
| Record: | 5-8 | 86-69 | |
| Points Scored: | 28.23 | 30.20 | 1.97 |
| Points Allowed: | 32.46 | 27.43 | 5.03 |
| Margin: | -4.23 | 2.77 | 7.00 |
| Total Points: | 60.69 | 57.63 | 3.06 |