| 9/4/2021 | Akron (2-10) | 10 | at | Auburn | 60 | MAC | ||
| 9/11/2021 | Alabama State (5-6) | 0 | at | Auburn | 62 | SWAC (1AA) | ||
| 9/18/2021 | Auburn | 20 | at | Penn State (7-6) | 28 | at B10 | ||
| 9/25/2021 | Georgia State (8-5) | 24 | at | Auburn | 34 | SBC | ||
| 10/2/2021 | Auburn | 24 | at | LSU (6-7,3-5) | 19 | |||
| 10/9/2021 | Georgia (14-1,9-1) | 34 | at | Auburn | 10 | |||
| 10/16/2021 | Auburn | 38 | at | Arkansas (9-4,4-4) | 23 | |||
| 10/30/2021 | Mississippi (10-3,6-2) | 20 | at | Auburn | 31 | |||
| 11/6/2021 | Auburn | 3 | at | Texas A&M (8-4,4-4) | 20 | |||
| 11/13/2021 | Mississippi State (7-6,4-4) | 43 | at | Auburn | 34 | |||
| 11/20/2021 | Auburn | 17 | at | South Carolina (7-6,3-5) | 21 | |||
| 11/27/2021 | Alabama (13-2,8-2) | 24 | at | Auburn | 22 | 4OT | ||
| 12/28/2021 | Houston (12-2) | 17 | vs | Auburn | 13 | Birmingham Bowl - Birmingham AL | AAC |
| vs Auburn | vs Other Opponents | Auburn compared to OOs | |
| Record: | 7-6 | 101-56 | |
| Points Scored: | 21.77 | 30.41 | 8.64 |
| Points Allowed: | 28.31 | 22.54 | 5.77 |
| Margin: | -6.54 | 7.87 | 14.41 |
| Total Points: | 50.08 | 52.95 | -2.87 |