| 9/4/2021 | Gettysburg | 7 | at | Bridgewater VA | 31 | Cen | ||
| Washington and Lee | 24 | at | Christopher Newport | 28 | @ NJAC | |||
| Randolph-Macon | 31 | at | Dickinson | 21 | @ Cen | |||
| Averett | 24 | at | Ferrum | 31 | ||||
| Greensboro | 7 | at | Guilford | 21 | USASC | |||
| Baldwin-Wallace | 45 | at | Hampden-Sydney | 24 | OAC | |||
| Methodist | 23 | at | Shenandoah | 28 | USASC | |||
| Southern Virginia | 41 | at | Wilmington | 34 | OT | @ OAC | ||
| 9/11/2021 | Christopher Newport | 27 | at | Averett | 30 | OT | NJAC | |
| Guilford | at | Methodist | Postponed | @ USASC | ||||
| Shenandoah | 30 | at | North Carolina Wesleyan | 21 | @ USASC | |||
| Catholic | 10 | at | Randolph-Macon | 62 | NEWMAC | |||
| Bridgewater VA | 35 | at | Southern Virginia | 17 | ||||
| Sewanee | 0 | at | Washington and Lee | 52 | SAA | |||
| Hampden-Sydney | 27 | at | Widener | 34 | @ MidAC | |||
| 9/18/2021 | Randolph-Macon | 31 | at | Bridgewater VA | 13 | |||
| Ferrum | 26 | at | Christopher Newport | 19 | @ NJAC | |||
| Averett | 48 | at | Greensboro | 2 | @ USASC | |||
| Shenandoah | 7 | at | Hampden-Sydney | 28 | ||||
| LaGrange | 38 | at | Southern Virginia | 34 | USASC | |||
| Guilford | 7 | at | Washington and Lee | 63 | ||||
| 9/25/2021 | Maryville | 10 | at | Averett | 47 | USASC | ||
| Bridgewater VA | 17 | at | Emory & Henry | 38 | @ D2Ind (D2) | |||
| Apprentice | 28 | at | Ferrum | 30 | None (Unk?) | |||
| Hampden-Sydney | 28 | at | Guilford | 27 | ||||
| Southern Virginia | 14 | at | Methodist | 37 | @ USASC | |||
| Washington and Lee | 25 | at | Randolph-Macon | 24 | ||||
| 10/2/2021 | Guilford | at | Apprentice | Canceled | @ None (Unk?) | |||
| North Carolina Wesleyan | 17 | at | Averett | 9 | USASC | |||
| Randolph-Macon | 44 | at | Ferrum | 21 | ||||
| Washington and Lee | 32 | at | Hampden-Sydney | 30 | ||||
| Southern Virginia | 17 | at | Maryville | 38 | @ USASC | |||
| Bridgewater VA | 27 | at | Shenandoah | 34 | ||||
| 10/9/2021 | Ferrum | 14 | at | Bridgewater VA | 10 | |||
| Shenandoah | 52 | at | Guilford | 25 | ||||
| Emory & Henry | 31 | at | Randolph-Macon | 34 | D2Ind (D2) | |||
| Huntingdon AL | 48 | at | Southern Virginia | 20 | USASC | |||
| Apprentice | 13 | at | Washington and Lee | 42 | None (Unk?) | |||
| 10/16/2021 | Apprentice | 7 | at | Bridgewater VA | 27 | None (Unk?) | ||
| Hampden-Sydney | 13 | at | Emory & Henry | 37 | @ D2Ind (D2) | |||
| Shenandoah | 23 | at | Ferrum | 24 | ||||
| Randolph-Macon | 58 | at | Guilford | 0 | ||||
| Averett | 25 | at | Huntingdon AL | 30 | @ USASC | |||
| Greensboro | 14 | at | Southern Virginia | 31 | USASC | |||
| 10/23/2021 | Methodist | 31 | at | Averett | 24 | USASC | ||
| Southern Virginia | 3 | at | Brevard | 7 | @ USASC | |||
| Ferrum | 28 | at | Hampden-Sydney | 42 | ||||
| Apprentice | 7 | at | Randolph-Macon | 49 | None (Unk?) | |||
| Emory & Henry | 7 | at | Shenandoah | 9 | D2Ind (D2) | |||
| Bridgewater VA | 0 | at | Washington and Lee | 17 | ||||
| 10/30/2021 | Hampden-Sydney | 38 | at | Apprentice | 21 | @ None (Unk?) | ||
| Washington and Lee | 30 | at | Emory & Henry | 28 | @ D2Ind (D2) | |||
| Guilford | 35 | at | Ferrum | 57 | ||||
| Shenandoah | 14 | at | Randolph-Macon | 45 | ||||
| Averett | 28 | at | Southern Virginia | 23 | ||||
| 11/6/2021 | LaGrange | 22 | at | Averett | 31 | USASC | ||
| Emory & Henry | 66 | at | Guilford | 13 | D2Ind (D2) | |||
| Bridgewater VA | 14 | at | Hampden-Sydney | 24 | ||||
| Southern Virginia | 10 | at | North Carolina Wesleyan | 19 | @ USASC | |||
| Apprentice | 16 | at | Shenandoah | 35 | None (Unk?) | |||
| Ferrum | 24 | at | Washington and Lee | 28 | ||||
| 11/13/2021 | Averett | 3 | at | Brevard | 40 | @ USASC | ||
| Guilford | 0 | at | Bridgewater VA | 43 | ||||
| Ferrum | 23 | at | Emory & Henry | 41 | @ D2Ind (D2) | |||
| Hampden-Sydney | 14 | at | Randolph-Macon | 37 | ||||
| Washington and Lee | 6 | at | Shenandoah | 14 | ||||
| 11/20/2021 | Washington and Lee | 0 | at | Mount Union | 52 | @ OAC |