| 9/4/2021 | Methodist | 23 | at | Shenandoah (7-3) | 28 | at ODC | ||
| 9/11/2021 | Guilford (1-7) | at | Methodist | Postponed | ODC | |||
| 9/18/2021 | Methodist | 38 | at | Maryville (4-6,3-3) | 21 | |||
| 9/25/2021 | Southern Virginia (2-8) | 14 | at | Methodist | 37 | ODC | ||
| 10/2/2021 | Methodist | 21 | at | Huntingdon AL (8-3,6-0) | 48 | |||
| 10/9/2021 | LaGrange (2-8,1-5) | 17 | at | Methodist | 34 | |||
| 10/23/2021 | Methodist | 31 | at | Averett (5-5) | 24 | at ODC | ||
| 10/30/2021 | Brevard (6-4,4-2) | 27 | at | Methodist | 31 | |||
| 11/6/2021 | Methodist | 40 | at | Greensboro (0-10,0-6) | 14 | |||
| 11/13/2021 | North Carolina Wesleyan (4-6,2-4) | 7 | at | Methodist | 38 |
| vs Methodist | vs Other Opponents | Methodist compared to OOs | |
| Record: | 2-7 | 37-53 | |
| Points Scored: | 22.22 | 22.32 | 0.10 |
| Points Allowed: | 32.56 | 27.30 | 5.26 |
| Margin: | -10.34 | -4.98 | 5.36 |
| Total Points: | 54.78 | 49.62 | 5.16 |