| 9/5/2021 | Emory & Henry | 36 | at | North Carolina Wesleyan (4-6) | 7 | at USASC | ||
| 9/11/2021 | Bluefield (6-5) | 46 | at | Emory & Henry | 45 | MSC (NAIA) | ||
| 9/18/2021 | Apprentice (1-7) | 7 | at | Emory & Henry | 63 | None (Unk?) | ||
| 9/25/2021 | Bridgewater VA (4-6) | 17 | at | Emory & Henry | 38 | ODC (D3) | ||
| 10/9/2021 | Emory & Henry | 31 | at | Randolph-Macon (9-1) | 34 | at ODC | ||
| 10/16/2021 | Hampden-Sydney (5-5) | 13 | at | Emory & Henry | 37 | ODC (D3) | ||
| 10/23/2021 | Emory & Henry | 7 | at | Shenandoah (7-3) | 9 | at ODC | ||
| 10/30/2021 | Washington and Lee (8-3) | 30 | at | Emory & Henry | 28 | ODC (D3) | ||
| 11/6/2021 | Emory & Henry | 66 | at | Guilford (1-7) | 13 | at ODC | ||
| 11/13/2021 | Ferrum (6-4) | 23 | at | Emory & Henry | 41 | ODC (D3) |
| vs Emory & Henry | vs Other Opponents | Emory & Henry compared to OOs | |
| Record: | 4-6 | 47-41 | |
| Points Scored: | 19.90 | 27.17 | 7.27 |
| Points Allowed: | 39.20 | 26.68 | 12.52 |
| Margin: | -19.30 | 0.49 | 19.79 |
| Total Points: | 59.10 | 53.85 | 5.25 |