| 9/4/2021 | Widener | 27 | at | Rowan (2-7) | 22 | at NJAC | ||
| 9/11/2021 | Hampden-Sydney (5-5) | 27 | at | Widener | 34 | ODC | ||
| 9/18/2021 | Lebanon Valley (5-5,4-5) | 3 | at | Widener | 24 | |||
| 9/25/2021 | Widener | 21 | at | Albright (2-8,1-7) | 7 | |||
| 10/2/2021 | Fairleigh Dickinson-Florham (7-4,5-3) | 27 | at | Widener | 3 | |||
| 10/9/2021 | Widener | 37 | at | Alvernia (0-10,0-8) | 7 | |||
| 10/16/2021 | Wilkes (6-4,5-4) | 13 | at | Widener | 30 | |||
| 10/23/2021 | Widener | 24 | at | Stevenson (5-6,5-3) | 29 | |||
| 11/6/2021 | Lycoming (8-3,7-2) | 0 | at | Widener | 17 | |||
| 11/13/2021 | Widener | 0 | at | Delaware Valley (11-1,8-0) | 27 | |||
| 11/20/2021 | Widener | 21 | at | Susquehanna (9-2) | 49 | at Cen |
| vs Widener | vs Other Opponents | Widener compared to OOs | |
| Record: | 4-7 | 56-48 | |
| Points Scored: | 19.18 | 26.78 | 7.60 |
| Points Allowed: | 21.64 | 23.45 | -1.81 |
| Margin: | -2.46 | 3.33 | 5.79 |
| Total Points: | 40.82 | 50.23 | -9.41 |