| 9/4/2021 | Southern Virginia (2-8) | 41 | at | Wilmington | 34 | OT | ODC | |
| 9/11/2021 | Wilmington | at | Heidelberg (7-2,6-2) | Cancelled | ||||
| 9/18/2021 | Ohio Northern (4-6,3-6) | 62 | at | Wilmington | 27 | |||
| 9/25/2021 | Wilmington | 14 | at | Muskingum (5-5,4-5) | 62 | |||
| 10/9/2021 | Mount Union (13-1,9-0) | 63 | at | Wilmington | 0 | |||
| 10/16/2021 | Marietta (4-6,4-5) | 35 | at | Wilmington | 7 | |||
| 10/23/2021 | Wilmington | 7 | at | Baldwin-Wallace (8-2,7-2) | 41 | |||
| 10/30/2021 | Wilmington | 7 | at | John Carroll (7-3,7-2) | 50 | |||
| 11/6/2021 | Capital (2-8,1-8) | 21 | at | Wilmington | 24 | |||
| 11/13/2021 | Wilmington | 37 | at | Otterbein (1-9,1-8) | 33 |
| vs Wilmington | vs Other Opponents | Wilmington compared to OOs | |
| Record: | 7-2 | 46-48 | |
| Points Scored: | 45.33 | 27.57 | -17.76 |
| Points Allowed: | 17.44 | 26.14 | -8.70 |
| Margin: | 27.89 | 1.43 | -26.46 |
| Total Points: | 62.77 | 53.71 | 9.06 |